BDBM26474 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide::GW-786034::JMC514632 Compound 13::Pazopanib::cid_10113978
SMILES CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1
InChI Key InChIKey=CUIHSIWYWATEQL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 26474
Affinity DataIC50: 30nMpH: 7.5 T: 2°CAssay Description:The assay uses purified baculovirus-expressed GST-VEGFR2 interacting with biotinylated peptide substrates. HTRF is based on the proximity of europium...More data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMT: 2°CAssay Description:To the assay kit, 2.5 µL of different concentrate of the test compounds, Pazopanib or water (control) were added and incubated for 1 h at room t...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Binding constant for VEGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Binding constant for VEGFR2 kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of VEGFR-2 (unknown origin) after 40 mins by kinase-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of GST-tagged human VEGFR2 C-terminal domain using (biotin-aminohexyl-EEEEYFELVAKKKK-NH2 substrate incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair